ERWIN CHARGAFF
Born: August 1905
Education: Columbia University Medical School
Year Of Major Discovery: 1949 - 1950
Erwin Chargaff is a Austro-Hungarian biochemist that discovered the base pairings between the nitrogenous bases of DNA.
Chargaff’s rule states that the ratio of pyrimidine to purine is a 1:1 ratio. This means that the numbers of adenines (A) paired to guanines (G) are equal and the number of base pairs between cytosine and thymine are equal (this is also applicable in the case of RNA whereby thymine is replaced by uracil. In other words the number or concentration of purines (A and G) is always equal to the number of pyrmidines (C and T) due to their interelationship however, this does not apply across all species.
Chargaff also proved that Levene's theory that nucleotides reoccur in the same order was incorrect. His reseearch extend across species and was able to deduce that other species do not have the same reoccuring pattern of nucleotides.
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| Nitrogenous Base pairings between pyrimidines and purenes |
Chargaff also proved that Levene's theory that nucleotides reoccur in the same order was incorrect. His reseearch extend across species and was able to deduce that other species do not have the same reoccuring pattern of nucleotides.
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